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ZHU Zhen
Department:Key Laboratory of MEMS, Ministry of Education Birthday:1984.02 Degree:Ph.D. Title:Researcher Post:PhD Supervisor, Vice Director of MEMS Lab Phone:025-83792632 Email:zhuzhen@seu.edu.cn
Personal Profile
Zhen Zhu is currently Associate Professor at the School of Electronic Science & Engineering and the School of Microelectronics, Southeast University, China. He received a B.Sc. and M.Sc. in electronic engineering at Southeast University in 2006 and 2008, respectively. He received his Ph.D. in bioengineering and bioelectronics from the Department of Biosystem Science and Engineering (D-BSSE), ETH Zurich, Switzerland in 2014. His current research focuses on the integration of microfluidics, microsystems, and electronics for biomedical applications.
Educational Experience

2009~2014    D-BSSE, ETH Zurich, Switzerland, Ph.D.

2006~2008    School of Electronic Science & Engineering, Southeast University, China, M.Sc.

2002~2006    School of Electronic Science & Engineering, Southeast University, China, B.Sc.

Work Experience

2014~present    School of Electronic Science & Engineering, School of Microelectronics, Key Laboratory of MEMS of Ministry of Education, Southeast University, China, Assistant Professor, Associate Professor, Professor

2014~2014        D-BSSE, ETH Zurich, Switzerland, Postdoc Researcher

ZHU Zhen
Department:Key Laboratory of MEMS, Ministry of Education Birthday:1984.02 Degree:Ph.D. Title:Researcher Post:PhD Supervisor, Vice Director of MEMS Lab Phone:025-83792632 Email:zhuzhen@seu.edu.cn
Teaching Course
Teaching Research
ZHU Zhen
Department:Key Laboratory of MEMS, Ministry of Education Birthday:1984.02 Degree:Ph.D. Title:Researcher Post:PhD Supervisor, Vice Director of MEMS Lab Phone:025-83792632 Email:zhuzhen@seu.edu.cn
Research Interests

Based on electronics and microelectronics, our interdisciplinary research focuses on the integration of microfluidics, biosensors, MEMS, embedded systems and AI into Lab-on-a-Chip systems applied in life science and precision medicine. 

1. EIS-based single-cell (S. cerevisiae) aging and lifespan determination, embryonic development monitoring and C. elegans worm sorting;

2. EIT-based worm locomotion and human regional lung function monitoring;

3. Machine-learning and neural-network algorithms for cell morphology analysis, animal behavior recognition and EIT image reconstruction.

Research Projects
Research Results

Book Chapters

[3] 朱真*译第18封装技术在生物电子中的应用,《器件和系统封装技术与应用:原书第2版》,(美)拉奥R.图马拉(Rao R. Tummala)主编,李晨等译,北京:机械工业出版社,2021.03

[2] Z. Zhu*, Y. Geng, and Y. Wang, Monitoring single S. cerevisiae cells with multifrequency electrical impedance spectroscopy in an electrode-integrated microfluidic device (Chapter 9). In: Marchisio M. A. (eds) Computational Methods in Synthetic Biology, Methods in Molecular Biology, vol 2189. Springer Nature, New York, NY, 2021. 

[1] Z. Zhu*, O. Frey, and A. Hierlemann, Wide-band Electrical Impedance Spectroscopy (EIS) Measures S. pombe Cell Growth in vivo (Chapter 13). In: Singleton T. (eds) Schizosaccharomyces pombe: Methods and ProtocolsMethods in Molecular Biology, vol 1721, Springer Nature, New York, NY, 2018.

Selected Publications

[33] Y. Wang, Z. Zhu*K. Liu, Q. Xiao, Y. Geng, F. Xu, S. Ouyang, K. Zheng, Y. Fan, N. Jin, X. Zhao, M. A. Marchisio, D. Pan, and Q.-A. HuangA high-throughput microfluidic diploid yeast long-term culturing (DYLC) chip capable of bud reorientation and concerted daughter dissection for replicative lifespan determination, Journal of Nanobiotechnology, 2022, 20: 171(IF 10.435https://doi.org/10.1186/s12951-022-01379-9 

[32] Y.-S. Tan, L. Wang, Y.-Y. Wang, Q.-E. He, Z.-H. LiuZ. Zhu*, K. Song*, B.-Z. Li*, and Y.-J. Yuan, Protein acetylation regulates xylose metabolism during adaptation of Saccharomyces cerevisiaeBiotechnology for Biofuels, 2021, 14: 241. (IF 6.040)

[31] Z. Zhang, X. HuangK. Liu, T. Lan, Z. Wangand Z. Zhu*Recent advances in electrical impedance sensing technology for single-cell analysisBiosensors, 2021, 11: 470. (IF 5.519https://doi.org/10.3390/bios11110470 

[30] 刘亚, 刘可, 黄庆安, 柏涛, 邱收, 张娜朱真*, 基于视频深度学习的小鼠恐惧情绪识别与分析方法研究生命科学仪器, 2021, 19(4): 37-44. 

[29] 刘可, 王颖瀛, 耿杨烨, 肖秦朱真*, 酿酒酵母单细胞形态参数精准提取算法的研究传感技术学报, 2021, 34(8): 1001-1006. 

[28] Z. Zhu*, Y. GengY. Wang, K. Liu, Z. Yi, X. Zhao, S. Ouyang, K. Zheng, Y. Fan and Z. Wang*Real-time monitoring of dissection events of single budding yeast in a microfluidic cell-culturing device integrated with electrical impedance biosensorFrontiers in Bioengineering and Biotechnology, 2021, 9: 783428. (IF 5.890)  https://doi.org/10.3389/fbioe.2021.783428


[27] Y. Geng, Z. Zhu*, Z. Zhang, F. Xu, M. A. Marchisio, Z. Wang, D. PanX. Zhao, and Q.-A. Huang, Design and 3D modeling investigation of a microfluidic electrode array for electrical impedance measurement of single yeast cells, Electrophoresis, 2021, 42: 1996-2009. (IF 3.535https://doi.org/10.1002/elps.202100028


[26] X.-P. Li, K.-Y. Qu, B. Zhou, F. Zhang, Y.-Y. Wang, O. D. Abodunrin, Z. Zhu, N.-P. Huang, Electrical stimulation of neonatal rat cardiomyocytes using conductive polydopamine-reduced graphene oxide-hybrid hydrogels for constructing cardiac microtissues, Colloids and Surfaces B: Biointerfaces, 2021, 205: 111844. (IF 5.268)

[25] Z. Zhu*Y. Wang, R. Peng, P. Chen,Y. Geng, B. He, S. Ouyang, K. Zheng, Y. Fan, D. Pan, N. Jin, F. Rudolf, and A. Hierlemann, A microfluidic single-cell array for in situ laminar-flow-based comparative culturing of budding yeast cells, Talanta, 2021, 231: 122401. (IF 6.057) https://doi.org/10.1016/j.talanta.2021.122401



[24] F. Zhang, K.-Y. Qu, B. Zhou, Y. Luo, Z. Zhu, D.-J. Pan, C. Cui, Y. Zhu, M.-L. Chen, and N.-P. Huang*, Design and fabrication of an integrated heart-on-a-chip platform for construction of cardiac tissue from human iPSC-derived cardiomyocytes and in situ evaluation of physiological function, Biosensors and Bioelectronics, 2021, 179: 113080. (IF 10.618)

[23] X. Xu, Z. Zhu*, Y. Wang, Y. Geng, F. Xu*, M. A. Marchisio, Z. Wang, and D. Pan, Investigation of daughter cell dissection coincidence of single budding yeast cells immobilized in microfluidic traps, Analytical and Bioanalytical Chemistry, 2021, 413: 2181-2193. (IF 4.157https://doi.org/10.1007/s00216-021-03186-x

[22] R. Cai, S. Guo, Y. Wu, S. Zhang, Y. Sun, S. Chen, P. Gao, C. Zhu, J. Chen, Z. Zhu, L. Sun, and F. Xu, Lattice-resolution visualization of anisotropic sodiation degrees and revelation of sodium storage mechanisms in todorokite-type MnO2 with in-situ TEM, Energy Storage Materials, 2021, 37: 345–353. (IF 17.789) 

[21] M. Dong, R. Fu, H. Min, Q. Zhang, H. Dong, Y. Pan, L. Sun*, W. Wei, M. Qin, Z. Zhu*, and F. Xu*, In situ liquid cell transmission electron microscopy investigation on the dissolution-regrowth mechanism dominating the shape evolution of silver nanoplates, Crystal Growth & Design, 2021, 21: 1314−1322. (IF 4.076)

[20] 张钊耿杨烨朱真*用于酵母细胞电阻抗检测的集成微电极阵列微流控芯片的有限元仿真研究电子器件, 2021, 44(2): 255-261. 


[19] 郭涛张钊杨浠潘德京彭年才朱真*新型冠状病毒检测方法的研究名医, 2020, 19: 76-77.

[18] K. Huang, Y. Geng, X. Zhang, D. Chen, Z. Cai, M. Wang, Z. Zhu*, and Z. Wang*, A wide-band digital lock-in amplifier and its application in microfluidic impedance measurement, Sensors, 2019, 19: 3519. (IF 3.576)

[17] K. Jia, Z. Lu, F. Zhou, Z. Xiong, R. Zhang, Z. Liu, Y. Ma, L. He, C. Li, Z. Zhu, D. Pan, and Z. Lian, Multiple sgRNAs facilitate base editingmediated i-stop to induce complete and precise gene disruption, Protein & Cell, 2019. (IF 14.870)

[16] Y. Geng, Z. Zhu*, Y. Wang, Y. Wang, S. Ouyang, K. Zheng, W. Ye, Y. Fan, Z. Wang, and D. Pan, Multiplexing microelectrodes for dielectrophoretic manipulation and electrical impedance measurement of single particles and cells in a microfluidic device, Electrophoresis, 2019, 40: 1436-1445. (IF 3.535https://doi.org/10.1002/elps.201800433

[15] Z. Zhu*, Y. Geng, Z. Yuan, S. Ren, M. Liu, Z. Meng, and D. Pan, A bubble-free microfluidic device for easy-to-operate immobilization, culturing and monitoring of zebrafish embryos, Micromachines, 2019, 10: 168. (IF 2.891)  https://doi.org/10.3390/mi10030168

[14] 耿杨烨潘任豪王颖瀛吴成均初慧杰朱真*,用于流式细胞电穿孔的微流控芯片的研究电子器件, 2019, 42(3): 545-550. 

[13] Z. Zhu*, W. Chen, B. Tian, Y. Luo, J. Lan, D. Wu, D. Chen, Z. Wang, and D. Pan, Using microfluidic impedance cytometry to measure C. elegans worms and identify their developmental stages, Sensors and Actuators B: Chemical, 2018, 275: 470-482. (IF 7.460https://doi.org/10.1016/j.snb.2018.07.169

[12] Z. Zhu*, X. Xu, L. Fang, D. Pan, and Q.-A. Huang, Investigation of geometry-dependent sensing characteristics of microfluidic electrical impedance spectroscopy through modeling and simulation, Sensors and Actuators B: Chemical, 2016, 235: 515-524. (IF 7.460https://doi.org/10.1016/j.snb.2016.05.092

[11] Z. Zhu*, P. Chen, K. Liu, and C. Escobedo, A versatile bonding method for PDMS and SU-8 and its application towards a multifunctional microfluidic device, Micromachines, 2016, 7: 230. (IF 2.891 https://doi.org/10.3390/mi7120230

[10] Z. Zhu*, O. Frey, N. Haandbæk, F. Franke, F. Rudolf, and A. Hierlemann, Time-lapse electrical impedance spectroscopy for monitoring the cell cycle of single immobilized S. pombe cells, Scientific Reports, 2015, 5: 17180. (IF 4.379)



[9] K. Liu, Z. Zhu*, X. Wang, D. Gonçalves, B. Zhang, A. Hierlemann, and P. Hunziker*, Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery, Nanoscale, 2015, 7: 16983-16993. (IF 7.790)

[8] Z. Zhu*, O. Frey, F. Franke, N. Haandbæk, and A. Hierlemann, Real-time monitoring of immobilized single yeast cells through multi-frequency electrical impedance spectroscopy, Analytical and Bioanalytical Chemistry, 2014, 406: 7015-7025. (IF 4.157)

[7] Z. Zhu*, O. Frey, D. S. Ottoz, F. Rudolf, and A. Hierlemann, Microfluidic single-cell cultivation chip with controllable immobilization and selective release of yeast cells, Lab on a Chip, 2012, 12: 906-915. (IF 6.799)

[6] Z. Zhou, Q.-A. Huang*Z. Zhu, and W. Li, An efficient simulation system for inclined UV lithography processes of thick SU-8 photoresists, IEEE Transactions on Semiconductor Manufacturing, 2011, 24(2): 294-303. (IF 2.874)

[5] Z. Zhu, Z. Zhou, Q.-A. Huang*, and W. Li, Modeling, simulation and experimental verification of inclined UV lithography for SU-8 negative thick photoresists, Journal of Micromechanics and Microengineering, 2008, 18: 125017-125027. (IF 1.881)

[4] Z. Zhou, Q.-A. Huang*, W. Li, M. Feng, W. Lu, and Z. Zhu, Improvement of the 2D dynamic CA method for photoresist etching simulation and its application to deep UV lithography simulations of SU-8 photoresists, Journal of Micromechanics and Microengineering, 2007, 17: 2538-2547. (IF 1.881)

[3] 朱真*黄庆安李伟华周再发冯明, SU-8胶曝光衍射效应的模拟及丙三醇补偿方法半导体学报, 2007, 28(12): 2011-2017.

[2] 冯明黄庆安李伟华周再发朱真, SU-8胶深紫外光刻模拟半导体学报, 2007, 28(9): 1465-1470.

[1] 冯明黄庆安*李伟华周再发朱真, SU-8胶在深紫外光源下的光强分布模拟传感技术学报, 2006, 19(5): 1470-1476.


[12] 朱真,徐星宇,王昊曦,杨剑坤,一种用于线虫运动行为和生理特征监测的微流控芯片,2022.03.29,中国,ZL202010474150.1

[11] Z. Zhu, M. Wang, Z. Zhang, Q.-A. Huang, Passive wireless device for microfluidic detection of multi-level droplet, 2022.02.15,US11249003B2

[10] 朱真,肖秦,一种用于固定带电极微流控芯片的夹具装置,2021.09.07,中国,ZL202010473207.6

[9]   朱真,孙治华,李子煜,一种基于PDMS微流体结构上集成聚氨酯薄膜的方法,2021.07.21,中国,ZL201811588911.5

[8]   朱真,王颖瀛,王蜜,潘德京,黄宁片,张宁,用于心肌细胞三维功能性培养的微流控芯片及制备方法及力学电学特性检测方法,2021.05.11,中国,ZL201810217635.5

[7]   朱真,厉俏单,金鼎鑫,俞峰,耿杨烨,一种用于细胞组织培养与实时监测的微流控芯片及其使用方法,2021.05.28,中国,ZL201810262702.5

[6]   朱真,耿杨烨,陈炜捷,田倍通,王颖瀛,潘任豪,用于秀丽线虫的微流控电阻抗检测分选芯片、系统及方法,2020.10.02,中国,ZL201711120212.3

[5]   朱真,耿杨烨,潘任豪,王颖瀛,微电极流控芯片及可调参数单细胞电穿孔装置,2020.08.11,中国,ZL201711082795.5

[4]   朱真,袁璋诣,许轩臻,一种用于微流控通道中气体去除的装置,2019.4.9,中国,ZL201610422673.5

[3]   朱真,陈攀,陈炜捷,田倍通,方磊,一种用于动物组织原位对照培养的微流控芯片,2018.5.4,中国,ZL201610838551.4

[2]   朱真,一种固定并连接带电极微流控芯片的通用型装置,2016.8.24,中国,ZL201510040767.1

[1]   朱真,一种以SU-8光刻胶和PDMS为基材的微流控芯片键合方法,2016.6.29,中国,ZL201510033501.4

ZHU Zhen
Department:Key Laboratory of MEMS, Ministry of Education Birthday:1984.02 Degree:Ph.D. Title:Researcher Post:PhD Supervisor, Vice Director of MEMS Lab Phone:025-83792632 Email:zhuzhen@seu.edu.cn
ZHU Zhen
Department:Key Laboratory of MEMS, Ministry of Education Birthday:1984.02 Degree:Ph.D. Title:Researcher Post:PhD Supervisor, Vice Director of MEMS Lab Phone:025-83792632 Email:zhuzhen@seu.edu.cn
Research Group Introduction
Members of the Research Group
Research Group Activities